| Gene | T10M13.8 |
| Putative Identification | G/T DNA mismatch repair enzyme |
| Position | 32344 to 39195, from the initial methionine to termination codon |
| Strand | + |
| EST match | none |
| Database match | T10M13.8 aligns well with sequences of G/T DNA mismatch repair enzymes from several organisms: fission yeast (P26359), baker's yeast (P25847), fruit fly, (P43248), mouse (P54276), and human (P52701). |
CDS: The table below lists the T10M13.8 exons and which algorithms selected the 5' and 3' termini (GS = GenScan, Gr = GRAIL, M = MZEF, NPG = NetPlantGene - selects splice sites only, not exons).
| Exon | Range | 5' | 3' |
|---|---|---|---|
| 1 | 32344 - 33289 | Gr | GS, M, NPG |
| 2 | 33427 - 33526 | GS, NPG | GS, Gr, M, NPG |
| 3 | 33733 - 33835 | GS, Gr, NPG | GS, NPG |
| 4 | 33922 - 33975 | M, NPG | M, NPG |
| 5 | 34060 - 34134 | GS, Gr, M, NPG | GS, Gr, M, NPG |
| 6 | 34328 - 34396 | GS, M, NPG | GS, M, NPG |
| 7 | 34526 - 34609 | GS, Gr, M, NPG | GS, Gr, M, NPG |
| 8 | 34762 - 34956 | GS, Gr, M, NPG | GS, M, NPG |
| 9 | 35048 - 35577 | GS, NPG | GS, M, NPG |
| 10 | 35654 - 35783 | GS, M | GS, M, NPG |
| 11 | 36129 - 36220 | GS, Gr | GS, Gr, NPG |
| 12 | 36319 - 36497 | GS, Gr, M, NPG | GS, M, NPG |
| 13 | 36573 - 36775 | GS | GS, Gr, NPG |
| 14 | 36874 - 36975 | GS, Gr, NPG | GS, Gr, M, NPG |
| 15 | 37136 - 37298 | GS, M, NPG | GS, M, NPG |
| 16 | 37680 - 37966 | GS, M, NPG | GS, Gr, M, NPG |
| 17 | 38060 - 38197 | GS, Gr, NPG | GS, Gr, NPG |
| 18 | 38365 - 38444 | Gr, M, NPG | GS, Gr, M, NPG |
| 19 | 38531 - 38630 | GS, Gr, M, NPG | GS, Gr, M, NPG |
| 20 | 38761 - 38890 | GS, Gr, M, NPG | GS, Gr, M, NPG |
| 21 | 38981 - 39195 | GS, Gr, M, NPG | GS, Gr |
Alternate exons not used in building the gene model. GenScan concatenates the gene model with that for PROLIFERA and so fails to predict an initial exon. Internal exons are from 32365 to 33289 and from 38299 to 38444. GRAIL predicts an initial exon from 32344 to 33311. Other GRAIL internal exons are from 33434 to 33526, from 33733 to 33859, from 34762 to 34876, from 35557 to 35582, from 37499 to 37545 and from 37699 to 37966. MZEF predicts exons from 32791 to 33289, from 35485 to 35577, from 36890 to 36975, from 38981 to 39043. NetPlantGene predicts many putative splice sites within this region. Notable sites include splice acceptors at 36064 (confidence score = 0.93) and donors at 34162 (0.90), at 34997 (0.90), and at 36204 (0.98).
Complete CDS of T10M13.8
ATGGCTCCGTCTCGCCGACAGATCAGCGGAAGATCTCCGTTGGTGAACCAGCAGCGTCAA ATCACCTCCTTCTTTGGGAAATCTGCTTCATCATCTTCTTCTCCGTCTCCATCTCCTTCA CCATCTCTCTCCAATAAGAAAACCCCCAAATCTAACAACCCTAACCCTAAATCTCCGTCT CCGTCACCATCTCCGCCTAAGAAAACCCCCAAATTGAACCCTAACCCTAGTTCTAATCTT CCTGCTCGTAGTCCTAGCCCTGGTCCTGATACTCCTTCTCCTGTACAGTCCAAGTTTAAG AAGCCCCTTCTCGTCATCGGACAGACACCTTCGCCTCCTCAATCGGTGGTAATTACTTAC GGTGACGAGGTGGTGGGGAAGCAAGTTAGGGTTTATTGGCCTTTGGATAAAAAATGGTAT GATGGGAGCGTGACGTTTTATGATAAGGGTGAGGGTAAGCATGTGGTTGAGTATGAAGAT GGGGAAGAAGAGTCTTTGGATTTGGGAAAGGAGAAGACTGAGTGGGTGGTTGGGGAAAAA TCAGGAGATAGGTTTAATCGATTGAAACGAGGCGCTTCGGCTTTGAGAAAAGTTGTGACG GATAGTGATGATGATGTGGAGATGGGTAATGTGGAAGAAGATAAAAGTGACGGTGATGAT TCTAGCGATGAGGATTGGGGAAAGAATGTTGGGAAGGAGGTTTGTGAGAGTGAAGAAGAT GATGTGGAGTTGGTTGATGAGAATGAAATGGATGAAGAAGAGTTGGTGGAAGAGAAAGAT GAAGAAACTTCTAAAGTTAATAGAGTATCCAAAACTGACTCTAGAAAGCGGAAGACTAGT GAAGTAACGAAATCAGGTGGTGAGAAGAAAAGCAAGACTGATACAGGCACTATCTTGAAA GGTTTTAAGGCTTCTGTTGTGGAGCCTGCGAAGAAGATTGGACAAGCTGATAGGGTGGTC AAGGGTTTGGAAGATAACGTGTTGGATGGGGATGCTCTTGCTAGATTTGGTGCTCGTGAT TCTGAGAAATTCCGCTTTTTGGGAGTAGACCGAAGGGATGCTAAAAGGAGACGCCCTACT GATGAGAATTATGATCCGAGGACACTCTACCTCCCTCCTGATTTTGTGAAAAAATTAACT GGAGGCCAGAGACAATGGTGGGAGTTTAAAGCAAAGCATATGGACAAAGTTGTATTCTTC AAGATGGGTAAATTCTATGAGCTTTTTGAGATGGATGCACATGTCGGAGCTAAGGAACTG GATATACAATACATGAAGGGAGAGCAACCTCATTGTGGATTTCCGGAGAAGAATTTTTCT GTAAACATTGAGAAATTAGTTAGAAAGGGCTATCGGGTTTTAGTTGTCGAACAAACAGAA ACACCTGATCAGCTGGAGCAACGCCGAAAAGAGACAGGTTCCAAGGATAAAGTTGTGAAG CGCGAAGTATGTGCAGTTGTTACAAAAGGCACGCTGACAGATGGGGAGATGCTATTAACT AATCCGGATGCATCTTATCTAATGGCCTTGACTGAAGGAGGAGAAAGTTTAACTAATCCT ACAGCAGAGCACAATTTTGGTGTATGTTTGGTTGATGTTGCGACACAGAAGATAATACTG GGCCAGTTTAAGGATGATCAAGATTGCAGTGCATTATCTTGCCTGCTATCTGAGATGAGG CCGGTGGAAATTATTAAACCAGCTAAGGTGTTGAGTTATGCAACAGAGAGAACAATAGTT AGACAAACCAGAAATCCCTTAGTAAATAATCTCGTTCCACTTTCTGAATTTTGGGATTCG GAGAAGACCATATATGAAGTTGGAATTATCTACAAGCGAATCAATTGTCAACCGTCTTCT GCTTATTCTAGTGAGGGAAAGATTCTAGGTGATGGTTCAAGCTTTCTTCCAAAAATGTTG TCTGAATTAGCAACTGAAGATAAGAATGGTAGCCTGGCACTCTCTGCTCTTGGTGGTGCC ATTTACTACCTGCGACAAGCATTCTTGGATGAGAGTCTGCTTAGATTTGCAAAGTTTGAA TCCCTGCCTTACTGTGATTTCAGCAACGTTAATGAGAAGCAGCACATGGTTCTTGATGCT GCTGCTCTTGAAAACCTTGAGATATTTGAAAACAGTAGAAATGGAGGCTATTCAGGAACG CTGTATGCTCAACTGAATCAATGTATCACTGCATCTGGGAAACGGTTACTGAAAACATGG CTGGCAAGACCTTTATATAATACGGAACTGATCAAGGAACGACAAGATGCTGTAGCAATT CTGCGGGGTGAAAATCTTCCGTACTCACTGGAATTCCGGAAGTCGTTGTCCAGACTTCCA GACATGGAACGGTTGATTGCACGTATGTTTTCTAGCATTGAAGCTAGTGGAAGAAATGGC GATAAAGTGGTGCTATATGAAGATACAGCTAAGAAGCAGGTACAGGAATTCATATCAACT CTACGTGGTTGTGAAACAATGGCAGAAGCATGCTCTTCTCTCCGTGCTATCTTGAAGCAT GATACATCCAGGCGGCTGCTTCATTTACTAACTCCTGGTCAAAGTCTTCCAAATATATCA TCCTCCATAAAGTATTTCAAGGATGCTTTTGACTGGGTAGAAGCTCACAATTCTGGACGT GTAATACCCCATGAAGGAGCAGATGAAGAGTATGATTGTGCCTGCAAAACAGTAGAAGAA TTTGAGTCCAGTTTGAAAAAACATCTGAAAGAGCAACGGAAATTACTCGGAGATGCATCA ATAAACTATGTTACAGTTGGAAAAGATGAATACCTCTTGGAAGTTCCTGAAAGTTTAAGT GGGAGTGTTCCTCATGATTATGAATTATGCTCATCGAAAAAGGGTGTCTCTCGATATTGG ACTCCTACCATAAAGAAATTATTAAAAGAGCTATCACAAGCAAAATCTGAAAAAGAGTCG GCCCTGAAGAGCATTTCACAGAGATTGATTGGACGTTTCTGCGAGCATCAAGAAAAATGG AGACAATTGGTTTCTGCAACAGCTGAGCTGGACGTGTTGATCAGCCTCGCTTTTGCAAGT GATTCTTATGAAGGAGTAAGATGCCGCCCAGTAATATCTGGTTCTACATCTGATGGTGTT CCACACTTGTCTGCCACTGGTCTAGGGCATCCAGTTCTAAGGGGTGATTCGTTAGGCAGA GGCTCTTTTGTACCAAATAATGTAAAGATAGGTGGTGCTGAGAAAGCCAGTTTCATCCTC CTCACAGGCCCTAATATGGGTGGAAAATCAACCCTTCTTCGCCAAGTTTGCTTGGCTGTA ATCTTGGCTCAGATTGGAGCAGATGTCCCAGCAGAAACCTTTGAGGTTTCGCCTGTTGAC AAAATTTGTGTCCGGATGGGTGCAAAAGATCATATCATGGCAGGACAAAGCACGTTTTTA ACAGAACTTTCAGAAACTGCGGTAATGTTGACATCAGCCACCCGAAACTCGCTGGTGGTG CTAGATGAGCTTGGACGAGGAACAGCCACATCAGATGGGCAAGCCATTGCGGAATCCGTA CTTGAGCACTTCATAGAAAAGGTGCAGTGTAGAGGATTCTTCTCTACTCATTATCATCGT CTCTCTGTGGATTATCAAACCAATCCAAAGGTCTCACTTTGCCATATGGCATGTCAAATA GGAGAAGGAATCGGTGGAGTAGAAGAAGTTACATTTCTCTATAGATTGACTCCTGGTGCA TGTCCTAAAAGTTATGGAGTTAACGTTGCTCGGTTAGCTGGTCTTCCAGATTACGTACTC CAGAGAGCCGTGATAAAATCCCAAGAATTCGAGGCTTTGTACGGTAAAAACCATAGAAAA ACCGATCATAAATTAGCAGCAATGATAAAGCAGATCATCAGCAGTGTTGCATCAGATTCT GATTACTCAGCTTCAAAGGACTCATTGTGTGAGCTACACTCCATGGCCAATACATTTCTC CGGTTAACCAACTAA
Protein translation
MAPSRRQISGRSPLVNQQRQITSFFGKSASSSSSPSPSPSPSLSNKKTPKSNNPNPKSPS PSPSPPKKTPKLNPNPSSNLPARSPSPGPDTPSPVQSKFKKPLLVIGQTPSPPQSVVITY GDEVVGKQVRVYWPLDKKWYDGSVTFYDKGEGKHVVEYEDGEEESLDLGKEKTEWVVGEK SGDRFNRLKRGASALRKVVTDSDDDVEMGNVEEDKSDGDDSSDEDWGKNVGKEVCESEED DVELVDENEMDEEELVEEKDEETSKVNRVSKTDSRKRKTSEVTKSGGEKKSKTDTGTILK GFKASVVEPAKKIGQADRVVKGLEDNVLDGDALARFGARDSEKFRFLGVDRRDAKRRRPT DENYDPRTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFEMDAHVGAKEL DIQYMKGEQPHCGFPEKNFSVNIEKLVRKGYRVLVVEQTETPDQLEQRRKETGSKDKVVK REVCAVVTKGTLTDGEMLLTNPDASYLMALTEGGESLTNPTAEHNFGVCLVDVATQKIIL GQFKDDQDCSALSCLLSEMRPVEIIKPAKVLSYATERTIVRQTRNPLVNNLVPLSEFWDS EKTIYEVGIIYKRINCQPSSAYSSEGKILGDGSSFLPKMLSELATEDKNGSLALSALGGA IYYLRQAFLDESLLRFAKFESLPYCDFSNVNEKQHMVLDAAALENLEIFENSRNGGYSGT LYAQLNQCITASGKRLLKTWLARPLYNTELIKERQDAVAILRGENLPYSLEFRKSLSRLP DMERLIARMFSSIEASGRNGDKVVLYEDTAKKQVQEFISTLRGCETMAEACSSLRAILKH DTSRRLLHLLTPGQSLPNISSSIKYFKDAFDWVEAHNSGRVIPHEGADEEYDCACKTVEE FESSLKKHLKEQRKLLGDASINYVTVGKDEYLLEVPESLSGSVPHDYELCSSKKGVSRYW TPTIKKLLKELSQAKSEKESALKSISQRLIGRFCEHQEKWRQLVSATAELDVLISLAFAS DSYEGVRCRPVISGSTSDGVPHLSATGLGHPVLRGDSLGRGSFVPNNVKIGGAEKASFIL LTGPNMGGKSTLLRQVCLAVILAQIGADVPAETFEVSPVDKICVRMGAKDHIMAGQSTFL TELSETAVMLTSATRNSLVVLDELGRGTATSDGQAIAESVLEHFIEKVQCRGFFSTHYHR LSVDYQTNPKVSLCHMACQIGEGIGGVEEVTFLYRLTPGACPKSYGVNVARLAGLPDYVL QRAVIKSQEFEALYGKNHRKTDHKLAAMIKQIISSVASDSDYSASKDSLCELHSMANTFL RLTN*
Protein motifs. The mutS class of mismatch repair enzymes contain a negatively charged, glycine-rich region about 80 amino acids to the C-terminal side of the ATP-binding site (P-loop).
| ATP/GTP-binding site motif A (P-loop) | |
| sequence | 1083 GPNMGGKS 1090 |
| DNA mismatch repair proteins mutS family signature | |
| sequence | 1157 SLVVLDELGRGTATSDG 1173 |
Alignment of G/T DNA mismatch repair enzyme sequences from selected organisms
1 60
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.cerevesiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mouse ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Human MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPEASPSPGGDAAWSEAGPGPRPL
A.thaliana ~~~~~~~~~~~~~~~~~~~~MAPSRRQISGRSPLVNQQRQITSFFGKSASSSSSPSPSPS
S.pombe ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
61 120
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.cerevisiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mouse ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~MEGYPWWPCLVYNHPFDGTFI
Human ARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFI
A.thaliana PSLSNKKTPKSNNPNPKSPSPSPSPPKKTPKLNPNPSSNLPARSPSPGPDTPSPVQSKFK
S.pombe ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
121 180
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.cerevisiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mouse RKKGKSVRVHVQFFDDSPTRG.WVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQRA
Human REKGKSVRVHVQFFDDSPTRG.WVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRA
A.thaliana KPLLVIGQTPSPPQSVVITYGDEVVGKQVRVYWPLDKKWYDGSVTFYD.KGEGKHVVEYE
S.pombe ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
181 240
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.cerevisiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mouse D.EALSKDTAERLQLAVCDEPSEPEEEEETEVHEAYLSDKSEEDNYNESEEEAQPSVQGP
Human D.EALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGS
A.thaliana DGEEESLDLGKEKTEWVVGEKSGDRFNRLKRGASALRKVVTDSDDDVEMGNVEEDKSDGD
S.pombe ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
241 300
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.cerevisiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mouse RRSSRQVKKR..RVISDSESDIGGSDVEFKPDTKQEGSSDDASSGVGDSDSEDLGTFGKG
Human RRSSRQIKKR..RVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKV
A.thaliana DSSDEDWGKNVGKEVCESEED....DVELVDENEMD...EEELVEEKDEETSKVNRVSKT
S.pombe ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
301 360
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.cerevisiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Mouse .APKRKRAMVAQGGLRRKSLKKETGSA.KR.ATPILSETKSTLSAFSAPQNSESQTHVSG
Human .ARKRKRMVTGNGSLKRKSSRKETPSATKQ.ATSISSETKNTLRAFSAPQNSESQAHVSG
A.thaliana DSRKRKTSEVTKSGGEKKS.KTDTGTILKGFKASVVEPAKKIGQADRVVKGLEDNVL...
S.pombe ~~~~~~~~~~MRGMSYNITHECDAINILSDNLHEGAISEDMVALSGPAIELLENNVGSSK
361 420
D.melanogaster ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~SNRQQAGTYPEYGHKCAS...NFIKFH
S.cerevisiae ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~MSSTRPELKFSDVSEERNFYKKY
Mouse GGNDSSGPTVWYHETLEWLKQK.KRRDEHRRRPDHPEFNPTTLYVPEEFLNSCTPGMRKW
Human GGDDSSRPTVWYHETLEWLKEE.KRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKW
A.thaliana DGDALARFGARDSEKFRFLGVD..RRDAKRRRPTDENYDPRTLYLPPDFVKKLTGGQRQW
S.pombe NSYQEDEGSSSIDENAPLISIKRKRRIRTVKSTSNKELVQRKASKPTKQKSVFTPLEQQY
421 480
D.melanogaster AKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKI...VYKSTAFIGALL.PDDKK...ET
S.cerevisiae TGLPKKPLKTIRLVDKGDYYTVIGSDAIFVADSV...YHTQSVLKNCQLDPVTAKNFHEP
Mouse WQLKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLI.FMKGNWAHSGFPEIAFGRFSDS
Human WQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLV.FMKGNWAHSGFPEIAFGRYSDS
A.thaliana WEFKAKHMDKVVFFKMGKFYELFEMDAHVGAKELDIQ.YMKGEQPHCGFPEKNFSVNIEK
S.pombe LELKKNYQETILAIEVGYKFRFFGKDAKIASEVLGISCYFEHNFLNASVPSYRIDYHLER
481 540
D.melanogaster LQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSSD......WEIEYRGSPGNLLQFEDIL
S.cerevisiae TKYVTVSLQVLATLLKLCLLDLGYKVEIYDKG.........WKLIKSASPGNIEQVNELM
Mouse LVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQT.YSVLDGDP
Human LVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQT.YSVLEGDP
A.thaliana LVRKGYRVLVVEQTETPDQLEQRRKETG..SK.DKVVKREVCAVVTKGTLTDGEMLLTNP
S.pombe LINFGLKVAVVRQTETAALKSTS.......SSRNTLFDRRVARVLTKGTTLDDSFFRFEQ
541 600
D.melanogaster FSNKEVLVGNSIISLLVKLD...G.GGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEAT
S.cerevisiae NMNIDSSI..IIASLKVQWN...SQDGNCIIGVAFIDTTAYKVGMLDIVDNEVYSNLESF
Mouse SEN....YSRYLLSLKEKEEETSGHT..RVYGVCFVDTSLGKFFIGQFSDDRHCSRFRTL
Human SEN....YSKYLLSLKEKEEDSSGHT..RAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTL
A.thaliana D.......ASYLMALTEGGESLTNPTAEHNFGVCLVDVATQKIILGQFKDDQDCSALSCL
S.pombe TQHGTLQASQFILCVADNVDKSKAKSGRVQVGLIAIQLSSGTTVYDHFQDDFLRSELQTR
601 660
D.melanogaster VVLLGPKECLLPSI......EGEYSAVKTLLDRNGVMI............TMPKKS..GD
S.cerevisiae LIQLGVKECLVQDLTSNSNSNAEMQKVINVIDRCGCVV............TLLKNSEFSE
Mouse VAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTL.LEGGYFT
Human VAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTL.LEEEYFR
A.thaliana LSEMRPVEIIKPAKVLSYATERTIVRQTRNPLVNNLVPLSEFWDSEKTIYEVGIIYKRIN
S.pombe LSHFQPCELIY.SNKLSSESVALLNHYVSTEKTCGRVVRVQHAVQQDVKLALENLQDFFS
661 720
D.melanogaster NDLLQDLNRLLRFAKGQQED......ATGLKELQLQLASNALKTAIKYL.DLVNDAGNLG
S.cerevisiae KDVELDLTKLL.....GDDL......ALSLPQKYSKLSMGACNALIGYL.QLLSEQDQVG
Mouse G..NGDSSTVLPLVLKGMTSESDSVG..LTPGEESELALSALGGIVFYLKKCLIDQELLS
Human EKLSDGIGVMLPQVLKGMTSESDSIG..LTPGEKSELALSALGGCVFYLKKCLIDQELLS
A.thaliana CQPSSAYSSEGKILGDGSSFLPKMLSELATEDKNGSLALSALGGAIYYLRQAFLDESLLR
S.pombe SKCIMSGSKIIELHMEKVKSLH.............SLSIICLDMAISYLMEFSL.EDLFV
721 780
D.melanogaster HYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHP.............SMPSYRWQSVLGVL
S.cerevisiae KYELVEHKLKEFMKLDASAIKALNLFPQGPQNPFGSNNLAVSGFTSAGNSGKVTSLFQLL
Mouse MANFEEYFPLDSDTVSTVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGNLLERL
Human MANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERV
A.thaliana FAKFESLPYCDFSNVN..........EKQHMVLDAAALENLEIFENSRNGGYSGTLYAQL
S.pombe ASNFYQ....PFDSISS.............MVLSKQALEGLELFVNQTDHTPVGSLFWVL
781 840
D.melanogaster DHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLL.ESPDTMETLSLDYLKRIPDILM
S.cerevisiae NHCKTNAGVRLLNEWLKQPLTNIDEINKRHDLVDYLI.DQIELRQMLTSEYLPMIPDIRR
Mouse DTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMA..VPYKVTEVADLLKKLPDLER
Human DTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMV..VPDKISEVVELLKKLPDLER
A.thaliana NQCITASGKRLLKTWLARPLYNTELIKERQDAVAILRGENLPYSL.EFRKSLSRLPDMER
S.pombe DRTYTRFGQRMLQRWLQKPLVDKENIIERLDAVEEL.AFNSNSQVQAIRKMLYRLPDLEK
841 900
D.melanogaster LTKKLMRRKANLQ......DLFRIYQVILRTPKILKVL.........HELDNSTIESVIC
S.cerevisiae LTKKLNKR.GNLE......DVLKIYQFSKRIPEIVQVFTSFLEDDSPTEPVNELVRSVWL
Mouse LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLEEVAG
Human LLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVAD
A.thaliana LIARMF...SSIEASGRNGDKVVLYEDT..AKKQVQEFISTLRGCETMAEACSSLRAILK
S.pombe GLSRIYYQRGFYKAA............SAFSKNSYSCFKSAL..LRRLIQQLPSISSIID
901 960
D.melanogaster APFKSFLKDLTGLK................QMVEQVVDFEAI.ERGEYLVKASFDSRLME
S.cerevisiae APLSHHVEPLSKFE................EMVETTVDLDAYEENNEFMIKVEFNEELGK
Mouse GFTSKTLKQVVTLQSKSPKGRFPDL.TAELQRWDTAFDHEKARKTGLITPKAGFDS...D
Human GFKSKILKQVISLQTKNPEGRFPDL.TVELNRWDTAFDHEKARKTGLITPKAGFDS...D
A.thaliana HDTSRRLLHLLT.....PGQSLPNI.SSSIKYFKDAFDWVEAHNSGRVIPHEGADE...E
S.pombe HFLG..MFDQKEAENNNKVDMFKDIDNFDLSEEPNDVDYELAQEI..........R...E
961 1020
D.melanogaster LQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYR
S.cerevisiae IRSKLDTLRDEIHSIHLDSAEDLGFDPDKKLKLENHHLHGWCMRLTRNDAKELRKHKKYI
Mouse YDQALADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATR.NLPEEYE
Human YDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTR.NLPEEYE
A.thaliana YDCACKTVEEFESSLKKHLKEQRKLLGDASINYVTVGKDEYLLEVPESL.SG.SVPHDYE
S.pombe LKMSILMVR...TEMDFHLQELRDYLEYPNLEFSIWGNVKFCIEVSKG..CK.KIPPDWI
1021 1080
D.melanogaster IVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELA
S.cerevisiae ELSTVKAGIFFSTKQLKSIANETNILQKEYDKQQSALVREIINITLTYTPVFEKLSLVLA
Mouse LKSTKKGCKRYWTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIA
Human LKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIA
A.thaliana LCSSKKGVSRYWTPTIKKLLKELSQAKSEKESALKSISQRLIGRFCEHQEKWRQLVSATA
S.pombe KLSSTRSLFRFHTPKIQSLLIELSSHEENLTISSEKIYRSFLSRISEHYNELRNVTTVLG
1081 1140
D.melanogaster QLDCLVSFAIAARSAPTPYVRPKML..E.EGARELVLEDVRHPCL..ELQEHVNFIANSV
S.cerevisiae HLDVIASFAHTSSYAPIPYIRPKLH..PMDSERRTHLISSRHPVL..EMQDDISFISNDV
Mouse VLDVLLCLANYSQGGDGPMCRPEIVLPGEDTHPFLEFKGSRHPCITKTFFG.DDFIPNDI
Human VLDVLLCLANYSRGGDGPMCRPVILLP.EDTPPFLELKGSRHPCITKTFFG.DDFIPNDI
A.thaliana ELDVLISLAFASDSYEGVRCRPVISGSTSDGVPHLSATGLGHPVLRGDSLGRGSFVPNNV
S.pombe TLDCLISFARISS..QSGYTRP......EFSDKELLIHESRHPMI..ELLSDKSFVPNHI
1141 1200
D.melanogaster DF.......KKEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSI
S.cerevisiae TL.......ESGKGDFLIITGPNMGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAIVDAI
Mouse LIGCEEEAEEHGKAYCVLVTGPNMGGKSTLIRQAGLLAVMAQLGCYVPAEKCRLTPVDRV
Human LIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRV
A.thaliana KIGGAE......KASFILLTGPNMGGKSTLLRQVCLAVILAQIGADVPAETFEVSPVDKI
S.pombe HLSSD.......GVRCLLITGPNMGGKSSFVKQLALSAIMAQSGCFVPAKSALLPIFDSI
1201 1260
D.melanogaster LGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAE
S.cerevisiae LCRVGAGDSQLKGVSTFMVEILETASILKNASKNSLIIVDELGRGTSTYDGFGLAWAIAE
Mouse FTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVK
Human FTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVK
A.thaliana CVRMGAKDHIMAGQSTFLTELSETAVMLTSATRNSLVVLDELGRGTATSDGQAIAESVLE
S.pombe LIRMGSSDNLSVNMSTFMVEMLETKEVLSKATEKSMVIIDELGRGTSTIDGEAISYAVLH
1261 1320
D.melanogaster HLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAA.........VADADDFTLLYQVRP
S.cerevisiae HIASKIGCFALFATHFHELTELSEKLPNVKNMHVVAHIEKNLKEQKHDDEDITLLYKVEP
Mouse ELAETIKCRTLFSTHYHSL.VEDYSKSVCVRLGHMA.CMVENECEDPSQETITFLYKFIK
Human ELAETIKCRTLFSTHYHSL.VEDYSQNVAVRLGHMA.CMVENECEDPSQETITFLYKFIK
A.thaliana HFIEKVQCRGFFSTHYHRL.SVDYQTNPKVSLCHMA.CQIGEGI..GGVEEVTFLYRLTP
S.pombe YLNQYIKSYLLFVTHFPSLGILERRFEGQLRCFHMGYLKSKEDFETSVSQSISFLYKLVP
1321 1380
D.melanogaster GVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQ..KKEDKALLEKIQVAIQQL
S.cerevisiae GISDQSFGIHVAEVVQFPEKIVKMAKRKANELDDLKTNNEDLKKAKLSLQEVNEGNIRLK
Mouse GACPKSYGFNAARLANLPEEVIQKGHRKAREFERM.NQSLRLFRGVCLATEKPTINGEAI
Human GACPKSYGFNAARLANLPEEVIQKGHRKAREFEKM.NQSLRLFREVCLASERSTVDAEAV
A.thaliana GACPKSYGVNVARLAGLPDYVLQRAVIKSQEFEALYGKNHRKTDHKLAAMIKQIISSVAS
S.pombe GVASKSYGLNVARMAGIPFSILSRATEISENYEKKHRNARKNVFIRKVAKLLMILNAEEI
1381 1437
D.melanogaster STAGNNVDINVEDLTQLVTQFTKDIEQLDSDYFKSVLATSEA~~~~~~~~~~~~~~~
S.cerevisiae ALLKEWIRKVKEEGLHDPSKITEEASQHKIQELLRAIANEPEKENDNYLKYIKALLL
Mouse HRLLALINGL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Human HKLLTLIKEL~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
A.thaliana DSDYSASKDSLCELHSMANTFLRLTN*~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
S.pombe DFKRLFYDLTAFEEI~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
written 30 Jul 97
updated 31 Jul 97
updated 3 Aug 98
Larry
Parnell