Gene:   T10P11.14.1
Putative Identification:   cullin-like 1
Position:   77659 to 81779, from initial methionine to the 3'-UTR
Strand:   -
EST match:   T45218, T43089, and T43414
Database match:   cullin and cullin-like sequences from several species,
	including human (cul-4A), fruitfly, nematode, and fission yeast.

The family of cullin and cullin-like sequences is broad and includes vasopressin-activated calcium-mobilizing receptor. Several genes in this family have been isolated from humans and the nematode C.elegans. Cullin proteins are thought to play a role in cell cycle regulation.


CDS:				exon terminus predicted by	Gr=Grail
					5'		3'	M=MZEF
	exon 1	81649 to 81779		EST,Gr		Gr
	exon 2	81463 to 81562		EST,M,Gr	EST,M,Gr
	exon 3	81103 to 81288		EST,M,Gr	EST,M,Gr
	exon 4	80973 to 81020		EST		EST
	exon 5	80744 to 80883				EST,M,Gr
	exon 6	80514 to 80565		M,Gr		
	exon 7	80224 to 80313		M		M,Gr
	exon 8	80061 to 80141		M,Gr		M,Gr
	exon 9	79879 to 79938		M		M,Gr
	exon 10	79769 to 79798		M,Gr		M,Gr
	exon 11	79578 to 79664		M,Gr		M,Gr
	exon 12	79337 to 79486		EST,M,Gr	M,Gr
	exon 13	79208 to 79263		EST,M,Gr	EST,M,Gr
	exon 14	78901 to 79021		EST,M,Gr	EST,M,Gr
	exon 15	78647 to 78808		EST,M,Gr	EST,M,Gr
	exon 16	78418 to 78561		EST,M,Gr	EST,M,Gr
	exon 17	78117 to 78335		EST,M,Gr	EST,M,Gr
	exon 18	77850 to 78017		M,Gr		M,Gr
	exon 19	77659 to 77760		Gr		Gr



Protein Translation:

MERKTIDLEQGWDYMQTGITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCTQKPPHDYSQ
QLYDKYREAFEEYINSTVLPALREKHDEFMLRELFKRWSNHKVMVRWLSRFFYYLDRYFI
ARRSLPPLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEI
GMGQMERYEEDFESFMLQDTSSERVAHYLHSSSEPKLVEKVQHELLVVFASQLLEKEHSG
CRALLRDDKVDDLSRMYRLYHKILRGLEPVANIFKQHVTAEGNALVQQAEDTATNQVANT
ASVQEQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVAGSSSAELLAT
FCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSANDD
HERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPGIDLTVTVLT
TGFWPSYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKFDQKAIEL
IVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYKILLKEPNTKTVS
QNDAFEFNSKFTDRMRRIKIPLPPVDERKKVVEDVDKDRRYAIDAAIVRIMKSRKVLGHQ
QLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA*



Alignment of cullin and cullin-like sequences from human, C. elegans, S. pombe,
Arabidopsis (T10P11.14.1), vasopressin activated calcium mobilizing receptor
(from rabbit and human), D. melanogaster, and S. cerevisiae.

                  1                                                         60
        Humcul-3  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
   Celeganscul-3  MSGRSGNGGQQKMRIRPFMATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYT 
Spombelin19-like  ~~~~MQRSAKLKIRAPRKFSANQVDFATH.WEVLQRAIGDIFQKSTSQLSFEELYRNAYI 
     T10P11.14.1  ~~~~~~~MERKTIDLEQGWDYMQTG.ITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCTQ 
       RabVACM-1  ~~MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQE.....SVTKQQWFDLFSDVHAVCLW 
       HumVACM-1  ~~MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQE.....SVTKQQWFDLFSDVHAVCLW 
        Humcul-1  MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSR.....YMELYTHVYNYCTS 
   Drolin19-like  ~MNRSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQ....YMRFYTHVYDYCTS 
   Celeganscul-1  ~~~~MTNSEPRRMTCDSEVVWKKLQDGLDVAYRRE.MAPKD.....YMTLYTSVYDYCTS 
        Humcul-2  ~~~~~~~MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERAT.....WNDRFSDIYALCVA 
   Celeganscul-2  ~~~~~~MYSLKPKVVEFDKVWVQLRPSIIDIINLRPITNVQ.....WHHKFSDVYDICVS 
ScerevisiaeCDC53  ~~~~~~MSETLPRSDDLEATWNFIEPGINQILGNEKNQAST.SKRVYKILSPTMYMEVYT 
   Celeganscul-4  MRGDTENRSDGEMDDVSTSSEIRHGNGFIENFRSQTGNSSRTTATNERIKKKLVIKNFKA 

                  61                                                       120
        Humcul-3  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 
   Celeganscul-3  MVLHKHGERLYNGLKDVIQDHM.........................ASVRIRIIESMNS 
Spombelin19-like  LVLHKYGEKLYNHVQDVIRSRLKEETV......PAIYKNYDASLLGNALLDIRKNDSYST 
     T10P11.14.1  KPPHDYSQQLYDKYREAFEEYINSTVL......PALREKHDEFM................ 
       RabVACM-1  .DDKGPA...............................KIHQALKEDILEFIKQAQARVL 
       HumVACM-1  .DDKGPA...............................KIHQALKEDILEFIKQAQARVL 
        Humcul-1  .VH..............................QFVGLELYKRLKEFLKNYLTNLLKDGE 
   Drolin19-like  .VSAAPSGR..........SSGKTGGA......QLVGKKLYDRLEQFLKSYLSELLTKFK 
   Celeganscul-1  .ITLSTSRRDGEDGRAESSTPARTAGA......DFVGHEMYQRVEEYVKAYVIAVCEKGA 
        Humcul-2  .YPEPLGERLYTETKIFLENHVRHLHK......RVLESEEQVLVM.YHRYW..EEYSKGA 
   Celeganscul-2  .IPTPLIERLYNEVKACIQEHVRQKRQ......DIVDVDPDLLLQEYHKMW..RVFHEGA 
ScerevisiaeCDC53  .AIYNYCVNKSRSSGHFSTDSRTGQST......ILVGSEIYEKLKNYLKNYILNFKQ... 
   Celeganscul-4  NANQNDVAMGDTNIDSTDGSVGRDWAVLSDNVFAILEDRKTVTTLEGLFSKVRSVCDKNQ 

                  121                                                      180
        Humcul-3  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
   Celeganscul-3  G............SFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYNLGLD 
Spombelin19-like  S...WSRSLEAAHRFLSSLVNSWKDHIVSMQMISSVLKYLDKVY.SKSADKVPVNENGIY 
     T10P11.14.1  ...............LRELFKRWSNHKVMVRWLSRFFYYLDRYFIARRS.LPPLNEVGLT 
       RabVACM-1  S...HQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKL 
       HumVACM-1  S...HQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKL 
        Humcul-1  D...LMDESV.LKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYE..IYSL 
   Drolin19-like  A...ISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYK..IYRL 
   Celeganscul-1  E....LSGEDLLKYYTTEWENFRISSKVMDGIFAYLNRHWIRRELDEGHENIYM..VYTL 
        Humcul-2  D......YMDCLYRYLSTQFIKKNKLTEADLQYGYGGVDMN........EPLME..IGEL 
   Celeganscul-2  I......FIHRLFGYLNKQFVKQKRCTDLDNFAQYAAFLQI........PDVKE..IGCL 
ScerevisiaeCDC53  .....SNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFD..VNTL 
   Celeganscul-4  SKVLYDRLVAIVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNI 

                  181                                                      240
        Humcul-3  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
   Celeganscul-3  AYRTEILRQN.GIGD..RIRDALLELIKLDRKSNQIN.WHGIKNACDMLISLGIDSR... 
Spombelin19-like  IFREVVLLNSFEIGE..KCVETILILVYLERKGNTIN.RPLINDCLDMLNSLPSENKKE. 
     T10P11.14.1  CFRDLVY...NELHS..KVKQAVIALVDKEREGEQID.RALLKNVLDIYVEIGMGQMER. 
       RabVACM-1  MLDTWNESIFSNIKN..RLQDSAMKLVHAERLGEAFD.SQLVIGVRESYVNLCSNPED.. 
       HumVACM-1  MLDTWNESIFSNIKN..RLQDSAMKLVHAERLGEAFD.SQLVIGVRESYVNLCSNPED.. 
        Humcul-1  ALVTWRDCLFRPLNK..QVTNAVLKLIEKERNGETIN.TRLISGVVQSYVELGLNEDDAF 
   Drolin19-like  ALVAWKGHLFQVLNE..PVTKAVLKSIEEERQGKLIN.RSLVRDVIECYVELSFNEEDTD 
   Celeganscul-1  ALVVWKRNLFNDLKD..KVIDAMLELIRSERTGSMIN.SRYISGVVECLVELGVDDSETD 
        Humcul-2  ALDMWRKLMVEPLQA..ILIRMLLREIKNDRGGEDPN.QKVIHGVINSFVHVEQ...... 
   Celeganscul-2  ALEIWKEDLVKTILP..QLVKLLLIAIDNDRKGNFPHIANEVSGVINSFVKMEETDFDVV 
ScerevisiaeCDC53  CLMTWKEVMFDPSKD..VLINELLDQVTLGREGQIIQRSN.ISTAIKSLVALGIDPQD.. 
   Celeganscul-4  FLHLDRIALGATDTEILPLWECFMQIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYP 

                  241                                                      300
        Humcul-3  ~~~~~~~ILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAE.NSASVYIKKVEARINE 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~NSA.....RARAAF.. 
   Celeganscul-3  ..............TVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLAQVEIAMHD 
Spombelin19-like  ..............TLYDVLFAPKFLSYTRNFY.EIESSTVIGVFGVVEYLKKAEKRFEE 
     T10P11.14.1  ................YEEDFESFMLQDTS.............................. 
       RabVACM-1  ............KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQ.NGVQNYMKYADAKLKE 
       HumVACM-1  ............KLQIYRDNFEKAYLDSTERFYRTQAPSYLQP.NGVQNYMKYADAKLKE 
        Humcul-1  AKG....P....TLTVYKESFESQFLADTERFYTRESTEFLQQ.NPVTEYMKKAEARLLE 
   Drolin19-like  AEQ....Q....KLSVYKQNFENKFIADTSAFYEKESDAFLST.NTVTEYLKHVENRLEE 
   Celeganscul-1  AKKDAETK....KLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQ 
        Humcul-2  ......YK.KKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESN.CSQYMEKVLGRLKD 
   Celeganscul-2  PAEGARYKARESTTAFYQESFEKPLLTDTEQYYSALAQKMLTDLS.CSEYMEQVIVLLEQ 
ScerevisiaeCDC53  ........LKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYL.EKHSVTEYIFEAHEIIKR 
   Celeganscul-4  VDSPLRSLVDMLQTVHVSEEFAKFLISQLREHYNNERIDKVPKMN.CNDYMEYCEDQINR 

                  301                                                      360
        Humcul-3  EIERVMHCLDKSTE...EPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ............................................................ 
   Celeganscul-3  EASRASRYLDKMTE...AKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIF 
Spombelin19-like  EKERSKNYLFTKIA...SPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQLVY 
     T10P11.14.1  .SERVAHYLHSSSE...PKLVEKVQHELLVVFASQLLEKEHSGCRALLRDDKVDDLSRMY 
       RabVACM-1  EEKRALRYLETRREC...NSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMF 
       HumVACM-1  EEKRALRYLETRREC...NSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMF 
        Humcul-1  EQRRVQV.......YLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMY 
   Drolin19-like  ETQRRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMY 
   Celeganscul-1  EDDRCQL.......YLNSSTKTPLATCCESVLISNQLDFLQRHFGGLLVDKRDDDLSRMF 
        Humcul-2  EEIRCR.......KYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMY 
   Celeganscul-2  EEMRAK.......KYLHESSVEKVITLCQKVMIKAHKDKLHAVCHDLITNEENKDLRNMY 
ScerevisiaeCDC53  EE.......KAMTIYWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLY 
   Celeganscul-4  YSQLVKVNFDE.....PSALKDVQATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMF 

                  361                                                      420
        Humcul-3  KLFSRVPNGLKTMCECMSSYLREQGKALVSE.......................EGEGKN 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ........................GTAIVIN.......................PEKDK. 
   Celeganscul-3  RIFKRIGDSVTVPGGGLKALLKAVSEYLNET.........GSNIVKNEDLLKN....... 
Spombelin19-like  ESFSRVELGVKSLKKYLAKYVAHHGKLINET.........TSQALEGKMAVGRLSSNATM 
     T10P11.14.1  RLYHKILRGLEPVANIFKQHVTAEGNALVQQ.............AEDTATNQVANTASVQ 
       RabVACM-1  SLMDKVPNGIEPMLKDLEEHIISAGL.....................ADMVAAAETITTD 
       HumVACM-1  SLMDKVPNGIEPMLKDLEEHIISAGL.....................ADMVAAAETITTD 
        Humcul-1  NLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA.ALN....................D 
   Drolin19-like  SLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAAN....................D 
   Celeganscul-1  KLCDRVPNGLDELRKSLENHIAKEGHQALERVA.MEAAT....................D 
        Humcul-2  VLLRAVSTGLPHMIQELQNHIHDEGLRATSN...LTQEN....................M 
   Celeganscul-2  RLLKPIQAGLSVMVKEFEEYVKKKGLEAVSR...LTGEN....................V 
ScerevisiaeCDC53  ALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLS 
   Celeganscul-4  NLCRQCVGGEDEVRTQFSKYLKKRGEKLIATCPDEDLVSELLAFKKKVDFIMTGSFKSA. 

                  421                                                      480
        Humcul-3  PVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS............... 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  ..DMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRP............... 
   Celeganscul-3  PVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLN.................. 
Spombelin19-like  ATLWVQKVLALWDRLNTIISTTMDADRSILNSLSDAFVTFVD.................. 
     T10P11.14.1  EQVLIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCN.................. 
       RabVACM-1  SEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGL 
       HumVACM-1  SEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGL 
        Humcul-1  PKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQS........ 
   Drolin19-like  PKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANS......... 
   Celeganscul-1  AKLYVKTLLEVHERYQSLVNRSFKNEPGFMQSLDKAATSFINNNAVTKRAPPQAQ..... 
        Humcul-2  PTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYR.......EP.KS.... 
   Celeganscul-2  PQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSK.......EPGQS.... 
ScerevisiaeCDC53  PKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSA.... 
   Celeganscul-4  .......................NDPVKMRQCLSDAFESFVNKQV............... 

                  481                                                      540
        Humcul-3  .....RSP.EYLSLFIDDKLKKG..VKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQ 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
       Humcul-4A  .....NKPAELIAKHVDSKLRAG..NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKK 
   Celeganscul-3  ...SNRQSPEFVALYMDDMLRS.G.LKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQ 
Spombelin19-like  ...GYTRAPEYISLFIDDNLKK.D.ARKAIEGSIEATLQNSVTLFRFISEKDVFEKYYKT 
     T10P11.14.1  KTVAGSSSAELLATFCDNILKKGG.SEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRK 
       RabVACM-1  KTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKA 
       HumVACM-1  KTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKA 
        Humcul-1  ....SSKSPELLARYCDSLLKKS..SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAK 
   Drolin19-like  ....ASKSPELLAKYCDLLLKKS..SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSK 
   Celeganscul-1  ....LTKSAELLARYCDQLLRKS..SKMPDEAELEELQTKIMVVFKYIDDKDVFSKFYTK 
        Humcul-2  ....VCKAPELLAKYCDNLLKKS..AKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYAR 
   Celeganscul-2  ....VPNGSERLARYTDGLLKKS..TKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSK 
ScerevisiaeCDC53  ....TSKTSEMLAKYSDILLKKA..TKPEVASDMSD..EDIITIFKYLTDKDAFETHYRR 
   Celeganscul-4  .....DRSAELISKHFHTLLHSSNKNVS.DDTTLDQMVDEAIVLFRYLRGKDVFEAYYKR 

                  541                                                      600
        Humcul-3  HLAR.............RLLTNKSVSDDSEKNMISKLKT.ECGCQFTSKLEGMFRDMSIS 
       Humcul-4B  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EKSMLSKLKH.ECGAAFTSKLEGMFKDMELS
       Humcul-4A  DLAK.............RLLVGKSASVDAEKSMLSKLKH.ECGAAFTSKLEGMFKDMELS 
   Celeganscul-3  YLAK.............RLLLDKSCSDDVEKALLAKLKT.ECGCQFTQKLENMFRDKELW 
Spombelin19-like  HLAKRYALIVFTVFNTFRLLNNRSISSDAELGMISRLKQ.EAGNVFTQKLEGMFNDMNLS 
     T10P11.14.1  KLAR.............RLLFDRSANDDHERSILTKLKQ.QCGGQFTSKMEGMVTDLTLA 
       RabVACM-1  HLTR.............RLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVS 
       HumVACM-1  HLTR.............RLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVS 
        Humcul-1  MLAK.............RLVHQNSASDDAEASMISKLKQA.CGFEYTSKLQRMFQDIGVS 
   Drolin19-like  MLAK.............RLVNHTSASDDAEAMMISKLKQT.CGYEYTVKLQRMFQDIGVS 
   Celeganscul-1  MFSK.............RLISELSASDEAEANFITKLKSM.CGYEYTARLSKMVNDTQVS 
        Humcul-2  MLAK.............RLIHGLSMSMDSEEAMINKLKQA.CGYEFTSKLHRMYTDMSVS 
   Celeganscul-2  MLAN.............RLIASTSISMDAEELMINKLKQA.CGYEFTSKLSRMFTDIGLS 
ScerevisiaeCDC53  LFAK.............RLIHGTSTSAEDEENIIQRLQAA.NSMEYTGKITKMFQDIRLS 
   Celeganscul-4  GLAK.............RLFLERSASVDAEKMVLCKLK.TECGSAFTYKLEGMFKDMDAS 

                  601                                                      660
        Humcul-3  NTTMDEFRQHLQATGVSL..GGVDLTVRVLTTGYWPTQSATPK..CNIPPAPRHAFEIFR 
       Humcul-4B  KDIMIQFKQYMQNQNVP...GNIELTVNILTMGYWPTYVPME...VHLPPEMVKLQEIFK
       Humcul-4A  KDIMVHFKQHMQNQSDS...GPIDLTVNILTMGYWPTYTPME...VHLTPEMIKLQEVFK 
   Celeganscul-3  LTLATSFRDWREAQP.TKMS..IDISLRVLTAGVWPTVQCNPVV...LPQELSVAYEMFT 
Spombelin19-like  QELLQEYKHNSALQS.AKPA..LDLNVSILASTFWPIDLSPHKIKCNFPKVLLAQIDQFT 
     T10P11.14.1  RENQNSFEDYLGSNPAANPG..IDLTVTVLTTGFWPSYKS...FDINLPSEMIKCVEVFK 
       RabVACM-1  EDLNQAFKEMHKNNKLALPAD..SVNIKILNAGAWS..RSSEKVFVSLPTELEDLIPEVE 
       HumVACM-1  EDLNQAFKEMHKNNKLALPAD..SVNIKILNAGAWS..RSSEKVFVSLPTELEDLIPEVE 
        Humcul-1  KDLNEQFKKHLTNSE...PLDL.DFSIQVLSSGSWPFQ...QSCTFALPSELERSYQRFT 
   Drolin19-like  KDLNSYFKQYLAEKN..LTMEI.DFGIEVLSSGSWPFQ...LSNNFLLPSELERSVRQFN 
   Celeganscul-1  KDLTADFKEKKADML..GQKSV.EFNVLVLSSGSWPTF...PTTPITLPQQLSKTIEIFG 
        Humcul-2  ADLNNKFNNFIKNQDTVIDLGI.SFQIYVLQAGAWPL.TQAPSSTFAIPQELEKSVQMFE 
   Celeganscul-2  QELSNNFDKHIADIKTV.QPDV.KF...............VPTQTMI....LQPVIQEFE 
ScerevisiaeCDC53  KILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSY..QEVEFKLPKELVPSHEKLK 
   Celeganscul-4  ENYGRLFNQYLEHMN....KEKANFTARVITPEYWPTY...DTYEINIPKEMRDTLTDYQ 

                  661                                                      720
        Humcul-3  RFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKH.....I 
       Humcul-4B  TFYLGKHSGRKLQWQSTLGHCVLKAEF.....KEGKKE......................
       Humcul-4A  AFYLGKHSGRKLQWQTTLGHAVLKAEF.....KEGKKE...................... 
   Celeganscul-3  QYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSGSGESMKERKPEHKI 
Spombelin19-like  DFYLSKHTGRKLLWYPSMGSADVRVNF........................KDRKYD... 
     T10P11.14.1  GFYETKTKHRKLTWIYSLGTCHINGKFDQKAIE........................... 
       RabVACM-1  EFYKKNHSGRKLHWHHLMSNGIIT...FKNEVGQYDLEVTTFQLAVLFAWNQRPREKISF 
       HumVACM-1  EFYKKNHSGRKLHWHHLMSNGIIT...FKNEVGQYDLEVTTFQLAVLFAWNQRPREKISF 
        Humcul-1  AFYASRHSGRKLTWLYQLSKGELVTNCFKNR...YTLQASTFQMAILLQYNT..EDAYTV 
   Drolin19-like  EFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFND..QLSFTV 
   Celeganscul-1  QFYNEKFNGRRLTWVYSQSRGEITSTAFPKK...YVFTATTAQMCTMLLFNE..QDSYTV 
        Humcul-2  LFYSQHFSGRKLTWLHYLCTGEVKMNYL...GKPYVAMVTTYQMAVLLAFNN..SETVSY 
   Celeganscul-2  KFYTGKHNGRKLTWLFNMSQGDVRLTYL...DKQHVAQMYVYQMAALLCFER..RDAILV 
ScerevisiaeCDC53  ESYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYND..ADVLTL 
   Celeganscul-4  DFYRVQHGNRNVKWHHGLASAVISASFRPGCKKE..LIATMYQTVILLLFNKCETWTVA. 

                  721                                                      780
        Humcul-3  LQVSTFQMTILMLFNNREKYT...FEEIQQETDIPERELVRALQSLACGKPTQRVLTKEP 
       Humcul-4B  LQVSLFQTLVLLMFNEGEEFS...LEEIKQATGIEDGELRRTLQSLACGK..ARVLAKNP
       Humcul-4A  FQVSLFQTLVLLMFNEGDGFS...FEEIKMATGIEDSELRRTLQSLACGK..ARVLIKSP 
   Celeganscul-3  LQVNTHQMIILLQLNHHNRISCQHEQQLMDELKIPERELKRNLQSLALGKASQRILVRKN 
Spombelin19-like  LNVSTIASVILLLFQDLKENQCLIFEEILEKTNIEVGDLKRNLQSLACAK..YKILLKDP 
     T10P11.14.1  LIVSTYQAAVLLLFNTTDKLS...YTEILAQLNLSHEDLVRLLHSLSCAK..YKILLKEP 
       RabVACM-1  ENLK..LATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDF...TEGTLFSVNQE 
       HumVACM-1  ENLK..LATELPDAELRRTLWSLVAFPKLKRQVFLYDPQVNSPKDF...TEGTLFSVNQE 
        Humcul-1  QQLT..DSTQIKMDILAQVLQILLKSKLLV.....LEDENANVDEVELK.PDTLIKLYLG 
   Drolin19-like  QQLQ..DNTQTQQENLIQVLQILLKAKVLT.....SSD.....NENSLT.PESTVELFLD 
   Celeganscul-1  EQIA..AATKMDEKSAPAIVGSLIKNLVLK.....ADTELQKEDEVPMT...ATVSLNKA 
        Humcul-2  KELQ..DSTQMNEKELTKTIKSLLDVKMIN.....HDSEKED......IDAESSFSLNMN 
   Celeganscul-2  KDIG..EEIGVSGDYLLKTIRTILDVTLLT.....CDDQN........LTADSLVRLNMS 
ScerevisiaeCDC53  ENIQ..EGTSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNIN 
   Celeganscul-4  ...EIVEHTKILEIEVVKNVLALLGGR..........DKPKVLQRVEGGGSEKKEGTVEN 

                  781                                                      840
        Humcul-3  .KSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAI 
       Humcul-4B  .KGKDIEDGDKFICNDDFKHKLFRIKINQIQMK..ETVEEQASTTERVFQDRQYQIDAAI
       Humcul-4A  .KGKEVEDGDKFIFNGEFKHKLFRIKINQIQMK..ETVEEQVSTTERVFQDRQYQIDAAI 
   Celeganscul-3  KGKDAIDMSDEFAVNDNFQSKLTRVKVQMVT.GKVESEPEIRETRQKVEDDRKLEVEAAI 
Spombelin19-like  KGRE.VNAGDKFYFNENFVSNLARIKISTVAQTRVEDDSERKRTLEKVDESRKHQADACI 
     T10P11.14.1  NTK.TVSQNDAFEFNSKFTDRMRRIKIP......LPPVDERKKVVEDVDKDRRYAIDAAI 
       RabVACM-1  FSLIKN........AKVQKRGKINLIGRLQLTTERMREEEN....EGIVQLRILRTRKLY 
       HumVACM-1  FSLIKN........AKVQKRGKINLIGRLQLTTERMREEEN....EGIVQLRILRTQEAI 
        Humcul-1  YKNKKL........RVNINV.P........MKTEQKQEQETTHK..NIEEDRKLLIQAAI 
   Drolin19-like  YKNKKR........RININQ.P........LKTELKVEQETVHK..HIEEDRKLLIQAAI 
   Celeganscul-1  YMNKKV........RVDLSKFT........MKQDAVRDTENVQK..NVEEDRKSVISACI 
        Humcul-2  FSSKRT........KFKI.TTS........MQKDTPQEMEQTRSA..VDEDRKMYLQAAI 
   Celeganscul-2  MTSKRM........KFRLQAPQ........VNKAVEKEQEAVANTFQVSQDRKYYMECAI 
ScerevisiaeCDC53  FASGVK........NDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACI 
   Celeganscul-4  LKNEKFVVNSKFTEK........RCRVRIAQVNIKTAVEETKEVKEEVNSDRQYKIDAAV 

                  841                                                       901
        Humcul-3  VRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA*
       Humcul-4B  VRIMKMRKTLSHNLLVSEVYNQLK..FPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA*
       Humcul-4A  VRIMKMRKTLGHNLLVSELYNQLK..FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA*
   Celeganscul-3  VRIMKARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA*
Spombelin19-like  VRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKRRIEALIEREYLQRQADNGRIYEYLA*
     T10P11.14.1  VRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA*
       RabVACM-1  IQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA*
       HumVACM-1  IQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA*
        Humcul-1  VRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA*
   Drolin19-like  VRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA*
   Celeganscul-1  VRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYEYLA*
        Humcul-2  VRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA*
   Celeganscul-2  VRIMKTRKVLKHNALVTEIMDQTKGRFSPDVPFIKKSIEDLIEKMYIQRTDQN.DEYQYLA*
ScerevisiaeCDC53  VRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGD.DGESYAYLA*
   Celeganscul-4  VRIMKARKQLNHQTLMTELLQQL..RFPVSTADIKKRLESLIEREYISRDPEEASSYNYVA*



created 12 Aug 97
Larry Parnell